For Healthcare Professionals

PNH: paroxysmal nocturnal hemoglobinuria

Paroxysmal nocturnal hemoglobinuria (PNH) is a progressive, yet rare,  disease that can cause thrombosis.  Learn more at these links:

PNH information portal - information for healthcare professionals on PNH from PNH Source, sponsored by Alexion Pharmaceuticals

Paroxysmal nocturnal hemoglobinuria and other complement-mediated hematological disorders.  Risitano AM.Immunobiology. 2012 Nov;217(11):1080-7.  - PubMed abstract and link

Signs and symptoms of PNH -from PNH Source

Clinical manifestations - from PNH Source

Diagnosis and testing - from PNH Source

Therapeutic options - from PNH Source

Soliris® (eculizumab) -  a treatment therapy approved for paroxysmal nocturnal hemoglobinuria (PNH), Alexion Pharmaceuticals

Patient resources  - links to resources, brochures, educational videos, support groups for patients with PNH, from PNH Source

PNH Guide -  from Aplastic Anemia & MDS International Foundation

PNH Information - from the National Organization for Rare Disorders

PNH Support Group - an online support group/discussion board

PNH Regional meetings -  meetings of patients and family from the National Organizations for Rare Disorders

OneSource patient support  program - OneSource is a program provided by Alexion Pharaceuticals and staffed by a Nurse Case Manager that provides patients with education, assistance with coverage issues and funding options, and treatment support.